human ERCC1 Over-expression AAV
This is an AAV expressing Human ERCC1.
AAV-208056
AAV-h-ERCC1
Ready-to-use AAV expressing Human ERCC1 (ERCC excision repair 1, endonuclease non-catalytic subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
COFS4; RAD10; UV20
Description (Vector)
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand.
Gene ID
2067
Gene Name (Vector)
ERCC excision repair 1, endonuclease non-catalytic subunit
Gene Symbol
ERCC1
HGNC ID
HGNC:3433
ORF Size (aa)
894
RefSeq ID
NM_001983
RefSeq Synonyms
NM_202001, NM_001983, NM_001166049, BC052813, BC008930,
Species
human
UniGene ID
Hs.435981
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.