human RASA1 shRNA silencing AAV

CMAVM; CM-AVM; GAP; GTPase-activating protein; p120; p120 RAS GTPase activating protein; p120GAP; p120RASGAP; PKWS; ras GTPase-activating protein 1; Ras p21 protein activator; RAS p21 protein activator (GTPase activating protein) 1; RASA; RASGAP; triphosphatase-activating protein

RASA1 is an inhibitory regulator of the Ras-cyclic AMP pathway. It Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P20936].

RASA1 is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues.

5921

RAS p21 protein activator 1

RAS p21 protein activator 1

RASA1

HGNC:9871

9606.0

3144

3144 bp

Ras GTPase-activating protein 1

NM_022650

NM_022650, NM_002890, BC033015,

Apoptosis,Axon Guidance,B-cell Receptor Signaling,Cancer,Cardiovascular,EGFR Signaling,EPO Signaling,Fc Receptor Signaling,HGF Signaling,Host-Virus Interactions,IGF-1 Signaling,Immunology,Insulin Signaling,Interleukin Signaling,MAPK Signaling,Neurobiology,Neurodevelopment,PDGF Signaling,Prostate Cancer,RNA Processing,SCF-KIT Signaling,Signal Transduction,T-cell Receptor Signaling,TPO Signaling,VEGF Signaling

cancer,cardiovascular,cell_biology,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,stem_cell_biology,transcription_translation

human

RASA1 is an inhibitory regulator of the Ras-cyclic AMP pathway. It Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P20936].

Hs.664080

P20936