human RARB shRNA silencing AAV

Name
AAV-h-RARB-shRNA

Cat No
shAAV-220748

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RARB.

shAAV-220748

AAV-h-RARB-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RARB (retinoic acid receptor beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HAP; MCOPS12; NR1B2; RARbeta1; RRB2

Description (Vector)

RARB encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. The gene expresses at least two transcript variants; one additional transcript has been described, but its full length nature has not been determined.

Gene ID

5915

Gene Name (Vector)

retinoic acid receptor beta

Gene Symbol

RARB

HGNC ID

HGNC:9865

ORF Size (aa)

1347

ORF Size (bp)

1347 bp

RefSeq ID

NM_000965

RefSeq Synonyms

NM_016152, NM_001290300, NM_001290277, NM_001290276, NM_001290266, NM_001290217, NM_001290216, NM_000965, BC060794,

Species

human

UniGene ID

Hs.654490

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.