human PTPRA shRNA silencing AAV

Name
AAV-h-PTPRA-shRNA

Cat No
shAAV-220331

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PTPRA.

shAAV-220331

AAV-h-PTPRA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PTPRA (protein tyrosine phosphatase, receptor type A). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

HEPTP; HLPR; HPTPA; HPTPalpha; LRP; PTPA; PTPRL2; R-PTP-alpha; RPTPA

Description (Vector)

PTPRA is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.

Gene ID

5786

Gene Name (Vector)

protein tyrosine phosphatase, receptor type A

Gene Symbol

PTPRA

HGNC ID

HGNC:9664

ORF Size (aa)

2382

ORF Size (bp)

2382 bp

RefSeq ID

NM_002836

RefSeq Synonyms

NM_080841, NM_080840, NM_002836, BC027308,

Species

human

UniGene ID

Hs.269577

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.