human PSMC3IP shRNA silencing AAV

Name
AAV-h-PSMC3IP-shRNA

Cat No
shAAV-220137

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PSMC3IP.

shAAV-220137

AAV-h-PSMC3IP-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PSMC3IP (PSMC3 interacting protein). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

GT198; HOP2; HUMGT198A; ODG3; TBPIP

Description (Vector)

PSMC3IP encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis. Alternative splicing of this gene results in multiple transcript variants.

Gene ID

29893

Gene Name (Vector)

PSMC3 interacting protein

Gene Symbol

PSMC3IP

HGNC ID

HGNC:17928

ORF Size (aa)

618

RefSeq ID

NM_013290

RefSeq Synonyms

NM_016556, NM_013290, NM_001256016, NM_001256015, NM_001256014, BC008792,

Species

human

UniGene ID

Hs.383019

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.