human PRX shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PRX.
shAAV-220046
AAV-h-PRX-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PRX (periaxin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMT4F
Description (Vector)
PRX encodes a protein involved in peripheral nerve myelin upkeep. The encoded protein contains 2 PDZ domains which were named after PSD95 (post synaptic density protein), DlgA (Drosophila disc large tumor suppressor), and ZO1 (a mammalian tight junction protein). Two alternatively spliced transcript variants have been described for this gene which encode different protein isoforms and which are targeted differently in the Schwann cell. Mutations in this gene cause Charcot-Marie-Tooth neuoropathy, type 4F and Dejerine-Sottas neuropathy.
Gene ID
57716
Gene Name (Vector)
periaxin
Gene Symbol
PRX
HGNC ID
HGNC:13797
ORF Size (aa)
4386
ORF Size (bp)
4386 bp
RefSeq ID
NM_020956
RefSeq Synonyms
NM_181882, NM_020956, BC067266,
Species
human
UniGene ID
Hs.205457
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.