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human PRMT6 shRNA silencing AAV

Name 
AAV-h-PRMT6-shRNA
Cat No 
shAAV-219907
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PRMT6.

shAAV-219907
AAV-h-PRMT6-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PRMT6 (protein arginine methyltransferase 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; histone-arginine N-methyltransferase PRMT6; HMT1 hnRNP methyltransferase-like 6; HRMT1L6; protein arginine N-methyltransferase 6
Description (eCommerce)
Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). HMGA1a (high mobility group A) has been identified as a substrate of PRMT6. The identification of HMGA1 as a substrate suggests that PRMT6 is involved in chromatin structure organization and gene regulation.
Description (Vector)
PRMT6 belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
Gene ID
55170
Gene Name (eCommerce)
protein arginine methyltransferase 6
Gene Name (Vector)
protein arginine methyltransferase 6
Gene Symbol
PRMT6
HGNC ID
HGNC:18241
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1128
ORF Size (bp)
1128 bp
Protein Name (eCommerce)
Protein arginine N-methyltransferase 6
RefSeq ID
NM_018137
RefSeq Synonyms
NM_018137, BC073866, BC063446, BC002729,
Research Areas
DNA Damage/Repair,Histone Modification,Host-Virus Interactions,Metabolism/Metabolic Process,Methyltransferase,Neurobiology,Transcription Factor/Regulator
Research Areas (Faceted)
genetics,transcription_translation,infectious_disease,metabolism,cell_biology,neurobiology,genetics,transcription_translation
Species
human
Target Sentence
Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). HMGA1a (high mobility group A) has been identified as a substrate of PRMT6. The identification of HMGA1 as a substrate suggests that PRMT6 is involved in chromatin structure organization and gene regulation.
UniGene ID
Hs.26006
UniProt ID (eCommerce)
Q96LA8

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.