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human PRMT6 shRNA silencing Adenovirus

Name 
Ad-h-PRMT6-shRNA
Cat No 
shADV-219907
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human PRMT6.

shADV-219907
Ad-h-PRMT6-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human PRMT6 (protein arginine methyltransferase 6). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; histone-arginine N-methyltransferase PRMT6; HMT1 hnRNP methyltransferase-like 6; HRMT1L6; protein arginine N-methyltransferase 6
Description (eCommerce)
Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). HMGA1a (high mobility group A) has been identified as a substrate of PRMT6. The identification of HMGA1 as a substrate suggests that PRMT6 is involved in chromatin structure organization and gene regulation.
Description (Vector)
PRMT6 belongs to the arginine N-methyltransferase family, which catalyze the sequential transfer of methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins, to form methylated arginine derivatives and S-adenosyl-L-homocysteine. This protein can catalyze both, the formation of omega-N monomethylarginine and asymmetrical dimethylarginine, with a strong preference for the latter. It specifically mediates the asymmetric dimethylation of Arg2 of histone H3, and the methylated form represents a specific tag for epigenetic transcriptional repression. This protein also forms a complex with, and methylates DNA polymerase beta, resulting in stimulation of polymerase activity by enhancing DNA binding and processivity.
Gene ID
55170
Gene Name (eCommerce)
protein arginine methyltransferase 6
Gene Name (Vector)
protein arginine methyltransferase 6
Gene Symbol
PRMT6
HGNC ID
HGNC:18241
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1128
ORF Size (bp)
1128 bp
Protein Name (eCommerce)
Protein arginine N-methyltransferase 6
RefSeq ID
NM_018137
RefSeq Synonyms
NM_018137, BC073866, BC063446, BC002729,
Research Areas
DNA Damage/Repair,Histone Modification,Host-Virus Interactions,Metabolism/Metabolic Process,Methyltransferase,Neurobiology,Transcription Factor/Regulator
Research Areas (Faceted)
genetics,transcription_translation,infectious_disease,metabolism,cell_biology,neurobiology,genetics,transcription_translation
Species
human
Target Sentence
Protein arginine methylation is a form of post-translational modification that is catalyzed by protein arginine methyltransferases (PRMTs). HMGA1a (high mobility group A) has been identified as a substrate of PRMT6. The identification of HMGA1 as a substrate suggests that PRMT6 is involved in chromatin structure organization and gene regulation.
UniGene ID
Hs.26006
UniProt ID (eCommerce)
Q96LA8

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.