human PRKCD shRNA silencing AAV

ALPS3; CVID9; MAY1; nPKC-delta; PKCD; protein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD

Protein kinase C delta (PKC-delta) is a member of the PKC family of serine-threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. PKC-delta is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types.

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed.

5580

protein kinase C delta

protein kinase C delta

PRKCD

HGNC:9399

9606.0

2031

2031 bp

Protein kinase C delta type

NM_006254

NM_212539, NM_006254, NM_001316327, BC043350,

Apoptosis,B-cell Receptor Signaling,BDNF Signaling,Cancer,Cardiology,Cardiovascular,Cell Cycle,Cytokine Signaling,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,EPO Signaling,Estrogen Signaling,Fc Receptor Signaling,FGF Signaling,Gene Expression,Glioma,GnRH Signaling,GPCR Signaling,Hedgehog Signaling,Host-Virus Interactions,IFN Signaling,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,Leptin Signaling,MAPK Signaling,Mitochondrion,mRNA Binding,Neurobiology,Neurodevelopment,NFAT Signaling,NGF Signaling,p53 Signaling,PDGF Signaling,RNA Processing,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Tumor Suppressors/Oncoproteins,VEGF Signaling,Wnt Signaling,Zinc-finger

cancer,cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation

human

Protein kinase C delta (PKC-delta) is a member of the PKC family of serine-threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. PKC-delta is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types.

Hs.155342

Q05655