human PPP6C shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PPP6C.
shAAV-219688
AAV-h-PPP6C-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PPP6C (protein phosphatase 6 catalytic subunit). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
PP6; PP6C; serine/threonine protein phosphatase catalytic subunit; serine/threonine-protein phosphatase 6 catalytic subunit
Description (eCommerce)
PPP6C is the protein phosphatase 6 catalytic subunit that is a member of the large PPP family of serine/threonine protein phosphatases. PPP6C is a type -2A phosphatase and is structurally related to PP2A and PP4. PP6 has been shown to play a role in the cell cycle through its regulation of cyclin D1. PPP6C has also been implicated in the negative control of NF-kappaB and TAK1 activation.
Description (Vector)
PPP6C encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X.
Gene ID
5537
Gene Name (eCommerce)
protein phosphatase 6 catalytic subunit
Gene Name (Vector)
protein phosphatase 6 catalytic subunit
Gene Symbol
PPP6C
HGNC ID
HGNC:9323
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
918
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 6 catalytic subunit
RefSeq ID
NM_002721
RefSeq Synonyms
NM_002721, NM_001123369, NM_001123355, BC006990,
Research Areas
Cell Cycle,Interleukin Signaling,Kinase/Phosphatase,Phosphatase,Signal Transduction,TNF Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,immunology,signal_transduction
Species
human
Target Sentence
PPP6C is the protein phosphatase 6 catalytic subunit that is a member of the large PPP family of serine/threonine protein phosphatases. PPP6C is a type -2A phosphatase and is structurally related to PP2A and PP4. PP6 has been shown to play a role in the cell cycle through its regulation of cyclin D1. PPP6C has also been implicated in the negative control of NF-kappaB and TAK1 activation.
UniGene ID
Hs.715605
UniProt ID (eCommerce)
O00743
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.