human PPP3CA shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PPP3CA.
shAAV-219675
AAV-h-PPP3CA-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PPP3CA (protein phosphatase 3 catalytic subunit alpha). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
calcineurin A alpha; calmodulin-dependent calcineurin A subunit alpha isoform; CALN; CALNA; CALNA1; CAM-PRP catalytic subunit; CCN1; CNA1; IECEE; IECEE1; PPP2B; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3 catalytic subunit alpha isozyme; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Description (eCommerce)
PPP3CA encodes the protein phosphatase 2B (PP2B) alpha catalytic subunit. PP2B, also known as calcineurin, is a holoenzyme that is comprised of a catalytic subunit associated with regulatory subunits. PP2B is a calcium regulated enzyme that is activated by calmodulin and participates in the signaling cascades involved in development of the nervous, cardiovascular, and musculoskeletal systems.
Gene ID
5530
Gene Name (eCommerce)
protein phosphatase 3 catalytic subunit alpha
Gene Name (Vector)
protein phosphatase 3 catalytic subunit alpha
Gene Symbol
PPP3CA
HGNC ID
HGNC:9314
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1536
ORF Size (bp)
1536 bp
Protein Name (eCommerce)
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
RefSeq ID
NM_000944
RefSeq Synonyms
NM_001130692, NM_001130691, NM_000944, BC025714,
Research Areas
Alzheimer's Disease,Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Axon Guidance,B-cell Receptor Signaling,Cardiac Hypertrophy,Cardiology,Cardiovascular,Cell Cycle,Fc Receptor Signaling,Gene Expression,GPCR Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Kinase/Phosphatase,MAPK Signaling,Meiosis,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodegeneration,Phosphatase,Signal Transduction,T-cell Receptor Signaling,VEGF Signaling,Wnt Signaling
Research Areas (Faceted)
cardiovascular,cell_biology,cell_cycle,developmental_biology,genetics,immunology,infectious_disease,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
PPP3CA encodes the protein phosphatase 2B (PP2B) alpha catalytic subunit. PP2B, also known as calcineurin, is a holoenzyme that is comprised of a catalytic subunit associated with regulatory subunits. PP2B is a calcium regulated enzyme that is activated by calmodulin and participates in the signaling cascades involved in development of the nervous, cardiovascular, and musculoskeletal systems.
UniGene ID
Hs.435512
UniProt ID (eCommerce)
Q08209
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.