human POU2F3 shRNA silencing AAV

Name
AAV-h-POU2F3-shRNA

Cat No
shAAV-219475

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human POU2F3.

shAAV-219475

AAV-h-POU2F3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human POU2F3 (POU class 2 homeobox 3). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

Epoc-1; OCT-11; OCT11; OTF-11; PLA-1; PLA1; Skn-1a

Description (Vector)

POU2F3 encodes a member of the POU domain family of transcription factors. POU domain transcription factors bind to a specific octamer DNA motif and regulate cell type-specific differentiation pathways. The encoded protein is primarily expressed in the epidermis, and plays a critical role in keratinocyte proliferation and differentiation. The encoded protein is also a candidate tumor suppressor protein, and aberrant promoter methylation of this gene may play a role in cervical cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

25833

Gene Name (Vector)

POU class 2 homeobox 3

Gene Symbol

POU2F3

HGNC ID

HGNC:19864

ORF Size (aa)

1311

ORF Size (bp)

1311 bp

RefSeq ID

NM_014352

RefSeq Synonyms

NM_014352, NM_001244682, BC101649,

Species

human

UniGene ID

Hs.227115

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.