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human POLR3K shRNA silencing AAV

Name 
AAV-h-POLR3K-shRNA
Cat No 
shAAV-219426
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human POLR3K.

shAAV-219426
AAV-h-POLR3K-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human POLR3K (RNA polymerase III subunit K). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C11; C11-RNP3; My010; RPC10; RPC11; RPC12.5
Description (Vector)
POLR3K encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.
Gene ID
51728
Gene Name (Vector)
RNA polymerase III subunit K
Gene Symbol
POLR3K
HGNC ID
HGNC:14121
ORF Size (aa)
327
RefSeq ID
NM_016310
RefSeq Synonyms
NM_016310, BC011932,
Species
human
UniGene ID
Hs.632223

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.