rat POLR3K shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Rat Polr3k.
shAAV-292951
AAV-r-POLR3K-shRNA
Ready-to-use AAV expressing shRNA for silencing of Rat Polr3k (RNA polymerase III subunit K). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
Gene ID
366277
Gene Name (Vector)
RNA polymerase III subunit K
Gene Symbol
Polr3k
ORF Size (aa)
327
RefSeq ID
NM_001014259
RefSeq Synonyms
NM_001014259, BC089990,
Species
rat
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.