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human POLR3B shRNA silencing AAV

Name 
AAV-h-POLR3B-shRNA
Cat No 
shAAV-219413
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human POLR3B.

shAAV-219413
AAV-h-POLR3B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human POLR3B (RNA polymerase III subunit B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C128; DNA-directed RNA polymerase III 127.6 kDa polypeptide; DNA-directed RNA polymerase III subunit B; DNA-directed RNA polymerase III subunit RPC2; HLD8; INMAP; interphase nucleus and mitotic apparatus associated protein; polymerase (RNA) III (DNA directed) polypeptide B; polymerase (RNA) III subunit B; RNA polymerase III subunit C2; RPC2
Description (eCommerce)
RPC2 is the second largest subunit of the 17 subunits that make up RNA polymerase III. RNA polymerase III is responsible for the synthesis of small RNA components that are part of the machinery involved in pre-mRNA splicing, and tRNA processing.
Description (Vector)
POLR3B encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
55703
Gene Name (eCommerce)
RNA polymerase III subunit B
Gene Name (Vector)
RNA polymerase III subunit B
Gene Symbol
POLR3B
HGNC ID
HGNC:30348
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3402
ORF Size (bp)
3402 bp
Protein Name (eCommerce)
DNA-directed RNA polymerase III subunit RPC2
RefSeq ID
NM_018082
RefSeq Synonyms
NM_018082, NM_001160708, BC046238,
Research Areas
Gene Expression,Host-Virus Interactions,Immunology,Innate Immunity,Neurobiology,Response to Virus,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,immunology,infectious_disease,neurobiology,transcription_translation
Species
human
Target Sentence
RPC2 is the second largest subunit of the 17 subunits that make up RNA polymerase III. RNA polymerase III is responsible for the synthesis of small RNA components that are part of the machinery involved in pre-mRNA splicing, and tRNA processing.
UniGene ID
Hs.610795
UniProt ID (eCommerce)
Q9NW08

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.