mouse POLR3B shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Polr3b.
shAAV-269049
AAV-m-POLR3B-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Polr3b (polymerase (RNA) III (DNA directed) polypeptide B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2700078H01Rik; A330032P03Rik; C85372; RPC2
Description (Vector)
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity). Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.
Gene ID
70428
Gene Name (Vector)
polymerase (RNA) III (DNA directed) polypeptide B
Gene Symbol
Polr3b
ORF Size (aa)
3402
ORF Size (bp)
3402 bp
RefSeq ID
NM_027423
RefSeq Synonyms
NM_027423, BC068143,
Species
mouse
UniGene ID
Mm.335007
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.