human PLRG1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PLRG1.
shAAV-219225
AAV-h-PLRG1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PLRG1 (pleiotropic regulator 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Cwc1; pleiotropic regulator 1; pleiotropic regulator 1 (PRL1 homolog, Arabidopsis); PRL1; PRP46; PRPF46; TANGO4; transport and golgi organization 4 homolog
Description (eCommerce)
Pleiotropic regulator 1 (PLRG1) has been shown to be a part of sub-spliceosomal protein complexes. It is highly conserved across species and is essential for pre-mRNA splicing. PLRG1 interacts with human CDC5. This interaction has also been shown to be essential to pre-mRNA splicing.
Description (Vector)
PLRG1 encodes a core component of the cell division cycle 5-like (CDC5L) complex. The CDC5L complex is part of the spliceosome and is required for pre-mRNA splicing. The encoded protein plays a critical role in alternative splice site selection. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
5356
Gene Name (eCommerce)
pleiotropic regulator 1
Gene Name (Vector)
pleiotropic regulator 1
Gene Symbol
PLRG1
HGNC ID
HGNC:9089
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1518
ORF Size (bp)
1518 bp
Protein Name (eCommerce)
Pleiotropic regulator 1
RefSeq ID
NM_002669
RefSeq Synonyms
NM_002669, NM_001201564, BC106004, BC020786,
Research Areas
Gene Expression,mRNA Processing,mRNA Splicing,RNA Processing,Signal Transduction,Spliceosome
Research Areas (Faceted)
signal_transduction,genetics,transcription_translation,cell_biology
Species
human
Target Sentence
Pleiotropic regulator 1 (PLRG1) has been shown to be a part of sub-spliceosomal protein complexes. It is highly conserved across species and is essential for pre-mRNA splicing. PLRG1 interacts with human CDC5. This interaction has also been shown to be essential to pre-mRNA splicing.
UniGene ID
Hs.249996
UniProt ID (eCommerce)
O43660
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.