human PLG shRNA silencing AAV

Name 
AAV-h-PLG-shRNA
Cat No 
shAAV-219205
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PLG.

shAAV-219205
AAV-h-PLG-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PLG (plasminogen). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
1500001L03Rik; AI836596; C87088; fibronectin type III domain-containing protein 5; fibronectin type III repeat-containing protein 2; PeP; peroxisomal protein; Pxp
Description (eCommerce)
Plasminogen contains 810 amino acid residues. It is a single chain glycoprotein with m.w. 90 kDa (Robbins et al., 1967), soluble in water; prepared from plasma that has been shown by certified test to be negative for HBsAg and for antibodies to HIV and HCV.Plasminogen is the inactive precursor of the protease plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.
Description (Vector)
PLG is a secreted blood zymogen that is activated by proteolysis and converted to plasmin and angiostatin. Plasmin dissolves fibrin in blood clots and is an important protease in many other cellular processes while angiostatin inhibits angiogenesis. Defects in this gene are likely a cause of thrombophilia and ligneous conjunctivitis. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
5340
Gene Name (eCommerce)
plasminogen
Gene Name (Vector)
plasminogen
Gene Symbol
PLG
HGNC ID
HGNC:9071
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
2433
ORF Size (bp)
2433 bp
Protein Name (eCommerce)
Plasminogen
RefSeq ID
NM_000301
RefSeq Synonyms
NM_001168338, NM_000301, BC060513,
Research Areas
Cardiovascular
Research Areas (Faceted)
cardiovascular
Species
human
Target Sentence
Plasminogen contains 810 amino acid residues. It is a single chain glycoprotein with m.w. 90 kDa (Robbins et al., 1967), soluble in water; prepared from plasma that has been shown by certified test to be negative for HBsAg and for antibodies to HIV and HCV.Plasminogen is the inactive precursor of the protease plasmin. Plasminogen is activated by the action of either tissue plasminogen activator (tPA), which primarily activates the fibrinolytic (thrombolytic) activity of plasmin, or urokinase plasminogen activator (uPA), which is associated with extracellular matrix remodeling and cell migration.
UniGene ID
Hs.143436
UniProt ID (eCommerce)
P00747

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.