human PLD1 shRNA silencing AAV

Name 
AAV-h-PLD1-shRNA
Cat No 
shAAV-219143
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PLD1.

shAAV-219143
AAV-h-PLD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PLD1 (phospholipase D1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
choline phosphatase 1; CVDD; hPLD1; phosphatidylcholine-hydrolyzing phospholipase D1; phospholipase D1; phospholipase D1, phosphatidylcholine-specific; PLD 1
Description (eCommerce)
PLD1 a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking [taken from NCBI Entrez Gene (Gene ID: 5337)].
Description (Vector)
PLD1 encodes a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking. Alternative splicing results in multiple transcript variants with both catalytic and regulatory properties.
Gene ID
5337
Gene Name (eCommerce)
phospholipase D1
Gene Name (Vector)
phospholipase D1
Gene Symbol
PLD1
HGNC ID
HGNC:9067
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3225
ORF Size (bp)
3225 bp
Protein Name (eCommerce)
Phospholipase D1
RefSeq ID
NM_002662
RefSeq Synonyms
NM_002662, NM_001130081, BC068976,
Research Areas
Cancer,EGFR Signaling,GnRH Signaling,Golgi Apparatus,Immunology,Innate Immunity,Interleukin Signaling,Metabolism/Metabolic Process,mTOR Signaling,Neurobiology,RAC1 Signaling,Rho Signaling,Signal Transduction,TSH Signaling
Research Areas (Faceted)
cancer,signal_transduction,cell_biology,immunology,signal_transduction,metabolism,signal_transduction,neurobiology
Species
human
Target Sentence
PLD1 a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking [taken from NCBI Entrez Gene (Gene ID: 5337)].
UniGene ID
Hs.382865
UniProt ID (eCommerce)
Q13393

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.