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human PDE1B shRNA silencing AAV

Name 
AAV-h-PDE1B-shRNA
Cat No 
shAAV-218462
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PDE1B.

shAAV-218462
AAV-h-PDE1B-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDE1B (phosphodiesterase 1B). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
HEL-S-79p; PDE1B1; PDES1B
Description (Vector)
PDE1B belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Gene ID
5153
Gene Name (Vector)
phosphodiesterase 1B
Gene Symbol
PDE1B
HGNC ID
HGNC:8775
ORF Size (aa)
1611
ORF Size (bp)
1611 bp
RefSeq ID
NM_000924
RefSeq Synonyms
NM_001315535, NM_001315534, NM_001288769, NM_001288768, NM_001165975, NM_000924, BC032226,
Species
human
UniGene ID
Hs.530871

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.