human PCSK9 shRNA silencing AAV

Name 
AAV-h-PCSK9-shRNA
Cat No 
shAAV-218414
Availability
Immediate
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PCSK9.

shAAV-218414
AAV-h-PCSK9-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PCSK9 (proprotein convertase subtilisin/kexin type 9). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
convertase subtilisin/kexin type 9 preproprotein; FH3; HCHOLA3; LDLCQ1; NARC1; NARC-1; neural apoptosis regulated convertase 1; Neural apoptosis-regulated convertase 1; PC9; Proprotein convertase 9; proprotein convertase subtilisin/kexin type 9; subtilisin/kexin-like protease PC9
Description (eCommerce)
The gene PCSK9, also known as NARC1, encodes for proprotein convertase subtilisin/kexin type 9. A member of the subtilisin-like proprotein convertase family, this protein is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia [taken from NCBI Entrez Gene (Gene ID: 255738)].
Description (Vector)
PCSK9 encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. The encoded protein is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the endoplasmic reticulum. The protein may function as a proprotein convertase. This protein plays a role in cholesterol homeostasis and may have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a third form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
Gene ID
255738
Gene Name (eCommerce)
proprotein convertase subtilisin/kexin type 9
Gene Name (Vector)
proprotein convertase subtilisin/kexin type 9
Gene Symbol
PCSK9
HGNC ID
HGNC:20001
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2079
ORF Size (bp)
2079 bp
Protein Name (eCommerce)
Proprotein convertase subtilisin/kexin type 9
RefSeq ID
NM_174936
RefSeq Synonyms
NM_174936, BC166619,
Research Areas
Apoptosis,Golgi Apparatus,Lysosomal Transport,Lysosome,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Neurogenesis,Signal Transduction
Research Areas (Faceted)
cell_biology,developmental_biology,metabolism,neurobiology,signal_transduction
Species
human
Target Sentence
The gene PCSK9, also known as NARC1, encodes for proprotein convertase subtilisin/kexin type 9. A member of the subtilisin-like proprotein convertase family, this protein is expressed in liver, intestine and kidney tissues and escorts specific receptors for lysosomal degradation. It plays a role in cholesterol and fatty acid metabolism. Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia [taken from NCBI Entrez Gene (Gene ID: 255738)].
UniGene ID
Hs.18844
UniProt ID (eCommerce)
Q8NBP7

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.