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human PCBP4 shRNA silencing AAV

Name 
AAV-h-PCBP4-shRNA
Cat No 
shAAV-218312
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PCBP4.

shAAV-218312
AAV-h-PCBP4-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PCBP4 (poly(rC) binding protein 4). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CBP; LIP4; MCG10
Description (Vector)
PCBP4 encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. PCBP4 is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G(2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.
Gene ID
57060
Gene Name (Vector)
poly(rC) binding protein 4
Gene Symbol
PCBP4
HGNC ID
HGNC:8652
ORF Size (aa)
1212
ORF Size (bp)
1212 bp
RefSeq ID
NM_020418
RefSeq Synonyms
NM_033010, NM_033008, NM_020418, NM_001174100, BC017098, BC004153, BC003008,
Species
human
UniGene ID
Hs.20930

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.