human PAX3 shRNA silencing AAV

Name 
AAV-h-PAX3-shRNA
Cat No 
shAAV-218272
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PAX3.

shAAV-218272
AAV-h-PAX3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PAX3 (paired box 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CDHS; HUP2; WS1; WS3
Description (Vector)
PAX3 is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini.
Gene ID
5077
Gene Name (Vector)
paired box 3
Gene Symbol
PAX3
HGNC ID
HGNC:8617
ORF Size (aa)
1455
ORF Size (bp)
1455 bp
RefSeq ID
NM_000438
RefSeq Synonyms
NM_181461, NM_181460, NM_181459, NM_181458, NM_181457, NM_013942, NM_001127366, NM_000438, BC114363, BC101302, BC101301, BC101300, BC101299,
Species
human
UniGene ID
Hs.42146

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.