human PARD6A shRNA silencing AAV

Name
AAV-h-PARD6A-shRNA

Cat No
shAAV-218220

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human PARD6A.

shAAV-218220

AAV-h-PARD6A-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PARD6A (par-6 family cell polarity regulator alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

PAR-6A; PAR6; PAR6alpha; PAR6C; TAX40; TIP-40

Description (Vector)

PARD6A is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene ID

50855

Gene Name (Vector)

par-6 family cell polarity regulator alpha

Gene Symbol

PARD6A

HGNC ID

HGNC:15943

ORF Size (aa)

1038

ORF Size (bp)

1038 bp

RefSeq ID

NM_016948

RefSeq Synonyms

NM_016948, NM_001037281, BC015626,

Species

human

UniGene ID

Hs.112933

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.