human PAK4 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PAK4.
shAAV-218158
AAV-h-PAK4-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PAK4 (p21 (RAC1) activated kinase 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; PAK-4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs; serine/threonine-protein kinase PAK 4
Description (eCommerce)
PAK4 is a member of the PAK family of serine/threonine p21-activating kinases. PAK4 is a target for the GTP-bound Rho GTPase, CDC42, and is an important factor that links Rho GTPases such as Ras to transformation. In this context, PAK4 is highly transforming, and has been found to be highly expressed in some tumor cell lines. PAK4 has been demonstrated to activate the JNK pathway and mediate the formation of filopodia and the reorganization of the actin cytoskeleton. PAK4 has also been found to function as a regulator of prosurvival pathways and senescence.
Description (Vector)
PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Gene ID
10298
Gene Name (eCommerce)
p21 (RAC1) activated kinase 4
Gene Name (Vector)
p21 (RAC1) activated kinase 4
Gene Symbol
PAK4
HGNC ID
HGNC:16059
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1281
ORF Size (bp)
1281 bp
Protein Name (eCommerce)
Serine/threonine-protein kinase PAK 4
RefSeq ID
NM_005884
RefSeq Synonyms
NM_005884, NM_001014835, NM_001014834, NM_001014832, NM_001014831, BC034511, BC025282, BC011368, BC002921,
Research Areas
Apoptosis,Axon Guidance,Breast Cancer,Cancer,Cell Cycle,Cytoskeleton,EPO Signaling,FGF Signaling,Golgi Apparatus,HGF Signaling,Immunology,Interleukin Signaling,JAK-STAT Signaling,Kidney Cancer,Kinase/Phosphatase,MicroRNAs in Cancer,Neurobiology,Neurodevelopment,Signal Transduction,T-cell Receptor Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction
Species
human
Target Sentence
PAK4 is a member of the PAK family of serine/threonine p21-activating kinases. PAK4 is a target for the GTP-bound Rho GTPase, CDC42, and is an important factor that links Rho GTPases such as Ras to transformation. In this context, PAK4 is highly transforming, and has been found to be highly expressed in some tumor cell lines. PAK4 has been demonstrated to activate the JNK pathway and mediate the formation of filopodia and the reorganization of the actin cytoskeleton. PAK4 has also been found to function as a regulator of prosurvival pathways and senescence.
UniGene ID
Hs.20447
UniProt ID (eCommerce)
O96013
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.