human PAF1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PAF1.
shAAV-218125
AAV-h-PAF1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PAF1 (PAF1 homolog, Paf1/RNA polymerase II complex component). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
F23149_1; hPAF1; Paf1, RNA polymerase II associated factor, homolog; pancreatic differentiation protein 2; PD2; RNA polymerase II-associated factor 1 homolog
Description (eCommerce)
Paf1 is a component of the Paf1 complex that was originally identified in yeast as an RNA-polymerase II (RNAP II)-associated complex. The Paf1 complex functions in multiple aspects of gene expression. Paf1 has been shown to play roles in transcript elongation, histone H2B monoubiquitination, H3 methylation, chromatin remodeling, mRNA 3’-end processing, and the coupling of transcriptional and posttranscriptional events.
Description (Vector)
PAF1 encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
54623
Gene Name (eCommerce)
PAF1 homolog, Paf1/RNA polymerase II complex component
Gene Name (Vector)
PAF1 homolog, Paf1/RNA polymerase II complex component
Gene Symbol
PAF1
HGNC ID
HGNC:25459
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1596
ORF Size (bp)
1596 bp
Protein Name (eCommerce)
RNA polymerase II-associated factor 1 homolog
RefSeq ID
NM_019088
RefSeq Synonyms
NM_019088, NM_001256826, BC013402, BC000017,
Research Areas
Cancer,Cell Cycle,Histone Modification,Mitochondrion,RNA Binding,RNA Processing,Signal Transduction,Transcription Factor/Regulator,Tumor Suppressors/Oncoproteins,Wnt Signaling
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
Paf1 is a component of the Paf1 complex that was originally identified in yeast as an RNA-polymerase II (RNAP II)-associated complex. The Paf1 complex functions in multiple aspects of gene expression. Paf1 has been shown to play roles in transcript elongation, histone H2B monoubiquitination, H3 methylation, chromatin remodeling, mRNA 3’-end processing, and the coupling of transcriptional and posttranscriptional events.
UniGene ID
Hs.466714
UniProt ID (eCommerce)
Q8N7H5
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.