human PACRG shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PACRG.
shAAV-218101
AAV-h-PACRG-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PACRG (PARK2 coregulated). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GLUP; HAK005771; PARK2CRG
Description (Vector)
PACRG encodes a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
135138
Gene Name (Vector)
PARK2 coregulated
Gene Symbol
PACRG
HGNC ID
HGNC:19152
ORF Size (aa)
774
RefSeq ID
NM_152410
RefSeq Synonyms
NM_152410, NM_001080379, NM_001080378, BC044227, BC030642,
Species
human
UniGene ID
Hs.25791
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.