human NUP62 shRNA silencing AAV

Name 
AAV-h-NUP62-shRNA
Cat No 
shAAV-217252
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NUP62.

shAAV-217252
AAV-h-NUP62-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NUP62 (nucleoporin 62). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
62 kDa nucleoporin; IBSN; nuclear pore glycoprotein p62; nucleoporin 62kD; nucleoporin 62kDa; nucleoporin Nup62; p62; SNDI
Description (eCommerce)
NUP62/p62 is an essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P37198].
Description (Vector)
The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. The protein encoded by this gene is a member of the FG-repeat containing nucleoporins and is localized to the nuclear pore central plug. This protein associates with the importin alpha/beta complex which is involved in the import of proteins containing nuclear localization signals. Multiple transcript variants of this gene encode a single protein isoform.
Gene ID
23636
Gene Name (eCommerce)
nucleoporin 62
Gene Name (Vector)
nucleoporin 62
Gene Symbol
NUP62
HGNC ID
HGNC:8066
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1569
ORF Size (bp)
1569 bp
Protein Name (eCommerce)
Nuclear pore glycoprotein p62
RefSeq ID
NM_012346
RefSeq Synonyms
NM_153719, NM_153718, NM_016553, NM_012346, NM_001193357, BC101107, BC101106, BC101105, BC101104, BC095410, BC050717, BC014842, BC003663,
Research Areas
Aging,Apoptosis,Cell Cycle,Cytoskeleton,Gene Expression,Host-Virus Interactions,Immunology,Metabolism/Metabolic Process,mRNA Processing,mRNA Transport,NF-kB Signaling,Ribonucleoprotein Transport,RNA Processing,RNA Transport,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,transcription_translation,immunology,infectious_disease,metabolism,signal_transduction
Species
human
Target Sentence
NUP62/p62 is an essential component of the nuclear pore complex. The N-terminal is probably involved in nucleocytoplasmic transport. The C-terminal is probably involved in protein-protein interaction via coiled-coil formation and may function in anchorage of p62 to the pore complex [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P37198].
UniGene ID
Hs.574492
UniProt ID (eCommerce)
P37198

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.