human NTRK3 shRNA silencing AAV

Name
AAV-h-NTRK3-shRNA

Cat No
shAAV-217167

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human NTRK3.

shAAV-217167

AAV-h-NTRK3-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NTRK3 (neurotrophic receptor tyrosine kinase 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

gp145(trkC); GP145-TrkC; TRKC

Description (Vector)

NTRK3 encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. Several transcript variants encoding different isoforms have been found for this gene.

Gene ID

4916

Gene Name (Vector)

neurotrophic receptor tyrosine kinase 3

Gene Symbol

NTRK3

HGNC ID

HGNC:8033

ORF Size (aa)

1839

ORF Size (bp)

1839 bp

RefSeq ID

NM_002530

RefSeq Synonyms

NM_002530, NM_001320135, NM_001320134, NM_001243101, NM_001012338, NM_001007156, BC013693,

Species

human

UniGene ID

Hs.706364

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.