human NTHL1 shRNA silencing AAV

Name 
AAV-h-NTHL1-shRNA
Cat No 
shAAV-217154
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NTHL1.

shAAV-217154
AAV-h-NTHL1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NTHL1 (nth like DNA glycosylase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase; bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase; DNA glycoslyase/AP lyase; DNA glycosylase/AP lyase; endonuclease III-like protein 1; FAP3; hNTH1; nth endonuclease III-like 1; NTH1; OCTS3
Description (eCommerce)
NTHL1 is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity [taken from NCBI Entrez Gene (Gene ID: 4913)].
Description (Vector)
NTHL1 is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity.
Gene ID
4913
Gene Name (eCommerce)
nth like DNA glycosylase 1
Gene Name (Vector)
nth like DNA glycosylase 1
Gene Symbol
NTHL1
HGNC ID
HGNC:8028
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
915
ORF Size (bp)
915 bp
Protein Name (eCommerce)
Endonuclease III-like protein 1
RefSeq ID
NM_002528
RefSeq Synonyms
NM_002528, NM_001318194, NM_001318193, BC003014,
Research Areas
DNA Damage/Repair,Mitochondrion
Research Areas (Faceted)
cell_biology,genetics,transcription_translation
Species
human
Target Sentence
NTHL1 is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic lyase activity [taken from NCBI Entrez Gene (Gene ID: 4913)].
UniGene ID
Hs.66196
UniProt ID (eCommerce)
P78549

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.