human NRD1 shRNA silencing AAV

Name 
AAV-h-NRD1-shRNA
Cat No 
shAAV-217073
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NRDC.

shAAV-217073
AAV-h-NRD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NRDC (nardilysin convertase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
convertase; hNRD1; hNRD2; nardilysin; nardilysin (N-arginine dibasic convertase); N-arginine dibasic convertase; NRD convertase; NRD1; NRD-C
Description (eCommerce)
NRD convertase cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43847].
Description (Vector)
NRD1 encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
4898
Gene Name (eCommerce)
nardilysin convertase
Gene Name (Vector)
nardilysin convertase
Gene Symbol
NRDC
HGNC ID
HGNC:7995
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
3453
ORF Size (bp)
3453 bp
Protein Name (eCommerce)
Nardilysin
RefSeq ID
NM_002525
RefSeq Synonyms
NM_002525, NM_001242361, NM_001101662, BC008775,
Research Areas
Cell Biology,EGFR Signaling,Neurobiology,Neurodevelopment,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,neurobiology,developmental_biology
Species
human
Target Sentence
NRD convertase cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O43847].
UniGene ID
Hs.584782
UniProt ID (eCommerce)
O43847

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.