human NR3C1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NR3C1.
shAAV-217054
AAV-h-NR3C1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NR3C1 (nuclear receptor subfamily 3 group C member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GCCR; GCR; GCRST; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; GR; GRL; Nuclear receptor subfamily 3 group C member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Description (eCommerce)
The glucocorticoid receptor (GR) functions as both a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues.
Description (Vector)
NR3C1 encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175).
Gene ID
2908
Gene Name (eCommerce)
nuclear receptor subfamily 3 group C member 1
Gene Name (Vector)
nuclear receptor subfamily 3 group C member 1
Gene Symbol
NR3C1
HGNC ID
HGNC:7978
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2334
ORF Size (bp)
2334 bp
Protein Name (eCommerce)
Glucocorticoid receptor
RefSeq ID
NM_000176
RefSeq Synonyms
NM_001204265, NM_001204264, NM_001204263, NM_001204262, NM_001204261, NM_001204260, NM_001204259, NM_001204258, NM_001024094, NM_001020825, NM_001018077, NM_001018076, NM_001018075, NM_001018074, NM_000176, BC015610,
Research Areas
Aging,Apoptosis,Brain Development,Cardiology,Cardiovascular,Gene Expression,Host-Virus Interactions,Interleukin Signaling,Metabolism/Metabolic Process,Mitochondrion,Neurobiology,Neurodevelopment,Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
The glucocorticoid receptor (GR) functions as both a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues.
UniGene ID
Hs.122926
UniProt ID (eCommerce)
P04150
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.