human NOD1 shRNA silencing AAV

Name
AAV-h-NOD1-shRNA

Cat No
shAAV-216854

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human NOD1.

shAAV-216854

AAV-h-NOD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NOD1 (nucleotide binding oligomerization domain containing 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

CARD4; CLR7.1; NLRC1

Description (Vector)

NOD1 encodes a member of the NOD (nucleotide-binding oligomerization domain) family. This member is a cytosolic protein. It contains an N-terminal caspase recruitment domain (CARD), a centrally located nucleotide-binding domain (NBD), and 10 tandem leucine-rich repeats (LRRs) in its C terminus. The CARD is involved in apoptotic signaling, LRRs participate in protein-protein interactions, and mutations in the NBD may affect the process of oligomerization and subsequent function of the LRR domain. This protein is an intracellular pattern-recognition receptor (PRR) that initiates inflammation in response to a subset of bacteria through the detection of bacterial diaminopimelic acid. Multiple alternatively spliced transcript variants differring in the 5' UTR have been described, but the full-length nature of these variants has not been determined.

Gene ID

10392

Gene Name (Vector)

nucleotide binding oligomerization domain containing 1

Gene Symbol

NOD1

HGNC ID

HGNC:16390

ORF Size (aa)

2862

ORF Size (bp)

2862 bp

RefSeq ID

NM_006092

RefSeq Synonyms

NM_006092, BC040339,

Species

human

UniGene ID

Hs.405153

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.