human NMT2 shRNA silencing AAV

Name 
AAV-h-NMT2-shRNA
Cat No 
shAAV-216838
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human NMT2.

shAAV-216838
AAV-h-NMT2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human NMT2 (N-myristoyltransferase 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
glycylpeptide N-tetradecanoyltransferase 2; glycylpeptide N-tetradecanoyltransferase 2 variant 3; glycylpeptide N-tetradecanoyltransferase 2 variant 4; myristoyl-CoA:protein N-myristoyltransferase 2; NMT 2; peptide N-myristoyltransferase 2; type II N-myristoyltransferase
Description (eCommerce)
Peptide N-myristoyltransferase 2 (NMT2) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue [taken from NCBI Entrez Gene (Gene ID: 9397)].
Description (Vector)
N-myristoyltransferase (NMT) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue. Biochemical evidence indicates the presence of several distinct NMTs, varying in apparent molecular weight and /or subcellular distribution. The predicted 498-amino acid of human NMT2 protein shares 77% and 96% sequence identity with human NMT1 and mouse Nmt2 comprise two distinct families of N-myristoyltransferases.
Gene ID
9397
Gene Name (eCommerce)
N-myristoyltransferase 2
Gene Name (Vector)
N-myristoyltransferase 2
Gene Symbol
NMT2
HGNC ID
HGNC:7858
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1497
ORF Size (bp)
1497 bp
Protein Name (eCommerce)
Glycylpeptide N-tetradecanoyltransferase 2
RefSeq ID
NM_004808
RefSeq Synonyms
NM_004808, NM_001308295, BC006376,
Research Areas
Acyltransferase,Golgi Apparatus,Host-Virus Interactions,Metabolism/Metabolic Process,Neurobiology,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology,infectious_disease,metabolism,neurobiology
Species
human
Target Sentence
Peptide N-myristoyltransferase 2 (NMT2) catalyzes the reaction of N-terminal myristoylation of many signaling proteins. It transfers myristic acid from myristoyl coenzyme A to the amino group of a protein's N-terminal glycine residue [taken from NCBI Entrez Gene (Gene ID: 9397)].
UniGene ID
Hs.60339
UniProt ID (eCommerce)
O60551

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.