human NAGS shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human NAGS.
shAAV-216293
AAV-h-NAGS-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human NAGS (N-acetylglutamate synthase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AGAS; ARGA
Description (Vector)
The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia.
Gene ID
162417
Gene Name (Vector)
N-acetylglutamate synthase
Gene Symbol
NAGS
HGNC ID
HGNC:17996
ORF Size (aa)
1107
RefSeq ID
NM_153006
RefSeq Synonyms
NM_153006, BC111713,
Species
human
UniGene ID
Hs.8876
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.