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human MMAA shRNA silencing AAV

Name 
AAV-h-MMAA-shRNA
Cat No 
shAAV-215547
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MMAA.

shAAV-215547
AAV-h-MMAA-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MMAA (methylmalonic aciduria (cobalamin deficiency) cblA type). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
cblA
Description (Vector)
MMAA is involved in the translocation of cobalamin into the mitochondrion, where it is used in the final steps of adenosylcobalamin synthesis. Adenosylcobalamin is a coenzyme required for the activity of methylmalonyl-CoA mutase. Defects in this gene are a cause of methylmalonic aciduria.
Gene ID
166785
Gene Name (Vector)
methylmalonic aciduria (cobalamin deficiency) cblA type
Gene Symbol
MMAA
HGNC ID
HGNC:18871
ORF Size (aa)
1257
ORF Size (bp)
1257 bp
RefSeq ID
NM_172250
RefSeq Synonyms
NM_172250, BC101181, BC101179, BC101178,
Species
human
UniGene ID
Hs.452864

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.