human MERTK shRNA silencing AAV

Name 
AAV-h-MERTK-shRNA
Cat No 
shAAV-215308
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human MERTK.

shAAV-215308
AAV-h-MERTK-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human MERTK (MER proto-oncogene, tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
c-Eyk; c-mer; c-mer proto-oncogene tyrosine kinase; MER; MER receptor tyrosine kinase; proto-oncogene c-Mer; receptor tyrosine kinase MerTK; RP38; STK kinase; Tyro12; tyrosine-protein kinase Mer
Description (eCommerce)
MerTK/c-mer is one of three members (Tyro3, Axl, and MerTK/c-mer) of the Tyro 3 subfamily of receptor tyrosine kinases (RTK). MerTK/c-mer was cloned from a human B-lymphoblastoid cDNA library. MerTK/c-mer Expression is absent in normal lymphocytes but is found to be ectopically expressed in lymphoblasts and in T-cell ALL cell lines. When activated MerTK/c-mer transmits antiapoptotic and transforming signals and may play a significant role in T-cell leukemogenesis.
Description (Vector)
MERTK is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Gene ID
10461
Gene Name (eCommerce)
MER proto-oncogene, tyrosine kinase
Gene Name (Vector)
MER proto-oncogene, tyrosine kinase
Gene Symbol
MERTK
HGNC ID
HGNC:7027
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2472
ORF Size (bp)
2472 bp
Protein Name (eCommerce)
Tyrosine-protein kinase Mer
RefSeq ID
NM_006343
RefSeq Synonyms
NM_006343, BC114918, BC114917,
Research Areas
Apoptosis,Cancer,Cardiovascular,Immunology,Kinase/Phosphatase,Signal Transduction,Spermatogenesis
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,signal_transduction
Species
human
Target Sentence
MerTK/c-mer is one of three members (Tyro3, Axl, and MerTK/c-mer) of the Tyro 3 subfamily of receptor tyrosine kinases (RTK). MerTK/c-mer was cloned from a human B-lymphoblastoid cDNA library. MerTK/c-mer Expression is absent in normal lymphocytes but is found to be ectopically expressed in lymphoblasts and in T-cell ALL cell lines. When activated MerTK/c-mer transmits antiapoptotic and transforming signals and may play a significant role in T-cell leukemogenesis.
UniGene ID
Hs.306178
UniProt ID (eCommerce)
Q12866

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.