human MEF2C shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MEF2C.
shAAV-215273
AAV-h-MEF2C-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MEF2C (myocyte enhancer factor 2C). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C5DELq14.3;DEL5q14.3;MADS box transcription enhancer factor 2, polypeptide C;Myocyte enhancer factor 2C;myocyte-specific enhancer factor 2C
Description (eCommerce)
MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It also plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. MEF2C is crucial for normal neuronal development, distribution, and electrical activity in the neocortex. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q06413].
Description (Vector)
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.
Gene ID
4208
Gene Name (eCommerce)
myocyte enhancer factor 2C
Gene Name (Vector)
myocyte enhancer factor 2C
Gene Symbol
MEF2C
HGNC ID
HGNC:6996
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1419
ORF Size (bp)
1419 bp
Protein Name (eCommerce)
Myocyte-specific enhancer factor 2C
RefSeq ID
NM_002397
RefSeq Synonyms
NM_002397, NM_001308002, NM_001193350, NM_001193349, NM_001193348, NM_001193347, NM_001131005, BC156603, BC152784,
Research Areas
Apoptosis,B Cell Receptor Signaling,BDNF Signaling,Cancer,Cardiac Development,Cardiac Hypertrophy,Cardiology,Cardiovascular,Epilepsy,Gene Expression,Host-Virus Interactions,Immunology,Innate Immunity,MAPK Signaling,Metabolism/Metabolic Process,Neurobiology,Neurodevelopment,Neurogenesis,NGF Signaling,Response to Virus,RNA Binding,Signal Transduction,TGF-beta Signaling,Toll-like Receptor Signaling,Transcription Factor / Regulator,Transcriptional Misregulation in Cancer
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,metabolism,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
MEF2C is a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. MEF2C controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. It also plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. MEF2C is crucial for normal neuronal development, distribution, and electrical activity in the neocortex. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q06413].
UniGene ID
Hs.653394
UniProt ID (eCommerce)
Q06413
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.