human MC1R shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MC1R.
shAAV-215130
AAV-h-MC1R-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MC1R (melanocortin 1 receptor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CMM5; MSH-R; SHEP2
Description (Vector)
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Gene ID
4157
Gene Name (Vector)
melanocortin 1 receptor
Gene Symbol
MC1R
HGNC ID
HGNC:6929
ORF Size (aa)
954
RefSeq ID
NM_002386
RefSeq Synonyms
NM_002386, BC080622, BC007856,
Species
human
UniGene ID
Hs.513829
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.