human MBP shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MBP.
shAAV-215123
AAV-h-MBP-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MBP (myelin basic protein). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
The protein encoded by the classic MBP gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called 'Golli-MBP') that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
Gene ID
4155
Gene Name (Vector)
myelin basic protein
Gene Symbol
MBP
HGNC ID
HGNC:6925
ORF Size (aa)
483
RefSeq ID
NM_001025092
RefSeq Synonyms
NM_002385, NM_001025101, NM_001025100, NM_001025092, NM_001025090, NM_001025081, BC143350, BC143348, BC101773, BC101771, BC080654, BC065248, BC008749,
Species
human
UniGene ID
Hs.551713
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.