human E2F8 Over-expression AAV

Name 
AAV-h-E2F8
Cat No 
AAV-207502
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human E2F8.

AAV-207502
AAV-h-E2F8

Ready-to-use AAV expressing Human E2F8 (E2F transcription factor 8). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
E2F family member 8; E2F-8; transcription factor E2F8
Description (eCommerce)
E2F8 along with E2F7, functions as an inhibitor of E2F-dependent transcription. E2F8 binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. E2F8 appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96AV8].
Description (Vector)
E2F8 encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Gene ID
79733
Gene Name (eCommerce)
E2F transcription factor 8
Gene Name (Vector)
E2F transcription factor 8
Gene Symbol
E2F8
HGNC ID
HGNC:24727
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2604
ORF Size (bp)
2604 bp
Protein Name (eCommerce)
Transcription factor E2F8
RefSeq ID
NM_024680
RefSeq Synonyms
NM_024680, NM_001256372, NM_001256371, BC126402, BC126400, BC028244,
Research Areas
Angiogenesis,Cell Cycle,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation
Species
human
Target Sentence
E2F8 along with E2F7, functions as an inhibitor of E2F-dependent transcription. E2F8 binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. E2F8 appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96AV8].
UniGene ID
Hs.523526
UniProt ID (eCommerce)
A0AVK6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.