human E2F8 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human E2F8.
shAAV-207502
AAV-h-E2F8-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human E2F8 (E2F transcription factor 8). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E2F family member 8; E2F-8; transcription factor E2F8
Description (eCommerce)
E2F8 along with E2F7, functions as an inhibitor of E2F-dependent transcription. E2F8 binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. E2F8 appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96AV8].
Description (Vector)
E2F8 encodes a member of a family of transcription factors which regulate the expression of genes required for progression through the cell cycle. The encoded protein regulates progression from G1 to S phase by ensuring the nucleus divides at the proper time. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Gene ID
79733
Gene Name (eCommerce)
E2F transcription factor 8
Gene Name (Vector)
E2F transcription factor 8
Gene Symbol
E2F8
HGNC ID
HGNC:24727
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2604
ORF Size (bp)
2604 bp
Protein Name (eCommerce)
Transcription factor E2F8
RefSeq ID
NM_024680
RefSeq Synonyms
NM_024680, NM_001256372, NM_001256371, BC126402, BC126400, BC028244,
Research Areas
Angiogenesis,Cell Cycle,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,transcription_translation
Species
human
Target Sentence
E2F8 along with E2F7, functions as an inhibitor of E2F-dependent transcription. E2F8 binds DNA independently of DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. E2F8 appears to regulate a subset of E2F-dependent genes whose products are required for normal cell cycle progession [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q96AV8].
UniGene ID
Hs.523526
UniProt ID (eCommerce)
A0AVK6
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.