human MAPKAPK3 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MAPKAPK3.
shAAV-214999
AAV-h-MAPKAPK3-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MAPKAPK3 (mitogen-activated protein kinase-activated protein kinase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3PK; chromosome 3p kinase; MAP kinase-activated protein kinase 3; MAPK-activated protein kinase 3; MAPKAP kinase 3; MAPKAP3; MAPKAP-K3; MAPKAPK-3; MDPT3; MK-3
Description (eCommerce)
Mitogen-activated protein kinase-activated protein kinase 3 (3pK) is a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs) and act as an integration point for multiple biochemical signals. 3pK was shown to be activated by growth inducers and stress stimulation of cell [taken from NCBI Entrez Gene (Gene ID: 7867)].
Description (Vector)
MAPKAPK3 encodes a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This kinase was shown to be activated by growth inducers and stress stimulation of cells. In vitro studies demonstrated that ERK, p38 MAP kinase and Jun N-terminal kinase were all able to phosphorylate and activate this kinase, which suggested the role of this kinase as an integrative element of signaling in both mitogen and stress responses. This kinase was reported to interact with, phosphorylate and repress the activity of E47, which is a basic helix-loop-helix transcription factor known to be involved in the regulation of tissue-specific gene expression and cell differentiation. Alternate splicing results in multiple transcript variants that encode the same protein.
Gene ID
7867
Gene Name (eCommerce)
mitogen-activated protein kinase-activated protein kinase 3
Gene Name (Vector)
mitogen-activated protein kinase-activated protein kinase 3
Gene Symbol
MAPKAPK3
HGNC ID
HGNC:6888
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1149
ORF Size (bp)
1149 bp
Protein Name (eCommerce)
MAP kinase-activated protein kinase 3
RefSeq ID
NM_004635
RefSeq Synonyms
NM_004635, NM_001243926, NM_001243925, BC010407, BC007591, BC001662,
Research Areas
CD95/FAS Signaling,EPO Signaling,Immunology,Innate Immunity,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,MAPK Signaling,Neurobiology,NGF Signaling,Signal Transduction,Toll-like Receptor Signaling,VEGF Signaling
Research Areas (Faceted)
signal_transduction,immunology,cell_biology,signal_transduction,neurobiology,immunology
Species
human
Target Sentence
Mitogen-activated protein kinase-activated protein kinase 3 (3pK) is a member of the Ser/Thr protein kinase family. This kinase functions as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase. MAP kinases are also known as extracellular signal-regulated kinases (ERKs) and act as an integration point for multiple biochemical signals. 3pK was shown to be activated by growth inducers and stress stimulation of cell [taken from NCBI Entrez Gene (Gene ID: 7867)].
UniGene ID
Hs.234521
UniProt ID (eCommerce)
Q16644
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.