human MAP3K7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MAP3K7.
shAAV-214938
AAV-h-MAP3K7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MAP3K7 (mitogen-activated protein kinase kinase kinase 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CSCF; FMD2; MEKK7; mitogen-activated protein kinase kinase kinase 7; TAK1; TGF1a; TGF-beta activated kinase 1; TGF-beta-activated kinase 1; transforming growth factor-beta-activated kinase 1
Description (eCommerce)
TAK1 (TGF-beta activated kinase 1) is also called mitogen-activated protein kinase kinase kinase 7 (MAP3K7). TAK1 is a serine/threonine protein kinase that mediates signals transduced by proinflammatory cytokines such as TGF-beta, tumor necrosis factor (TNF), interleukin-1 (IL-1) and wnt family ligands. TAK1 transduces signals by stimulating a MAPK pathway that ultimately stimulates JNK (c-terminal jun kinase) and p38 MAPKs. TAK1 is also an activator of the Ikappa B kinase that leads to the activation of NFkappa-B.
Description (Vector)
MAP3K7 is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
Gene ID
6885
Gene Name (eCommerce)
mitogen-activated protein kinase kinase kinase 7
Gene Name (Vector)
mitogen-activated protein kinase kinase kinase 7
Gene Symbol
MAP3K7
HGNC ID
HGNC:6859
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1740
ORF Size (bp)
1740 bp
Protein Name (eCommerce)
Mitogen-activated protein kinase kinase kinase 7
RefSeq ID
NM_145332
RefSeq Synonyms
NM_145333, NM_145332, NM_145331, NM_003188, BC017715,
Research Areas
Angiogenesis,Apoptosis,B-cell Receptor Signaling,Cardiology,Cardiovascular,CD95/FAS Signaling,Cytokine Signaling,DNA Damage/Repair,EPO Signaling,Fc Receptor Signaling,Histone Modification,Host-Virus Interactions,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,JNK Signaling,Kinase/Phosphatase,MAPK Signaling,Neurobiology,Neurodevelopment,NF-kB Signaling,Notch Signaling,RANKL-RANK Signaling,Signal Transduction,T-cell Receptor Signaling,TGF-beta Signaling,TNF Signaling,Toll-like Receptor Signaling,Transcription Factor/Regulator,TWEAK Signaling,VEGF Signaling,Wnt Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,genetics,immunology,infectious_disease,neurobiology,signal_transduction,transcription_translation
Species
human
Target Sentence
TAK1 (TGF-beta activated kinase 1) is also called mitogen-activated protein kinase kinase kinase 7 (MAP3K7). TAK1 is a serine/threonine protein kinase that mediates signals transduced by proinflammatory cytokines such as TGF-beta, tumor necrosis factor (TNF), interleukin-1 (IL-1) and wnt family ligands. TAK1 transduces signals by stimulating a MAPK pathway that ultimately stimulates JNK (c-terminal jun kinase) and p38 MAPKs. TAK1 is also an activator of the Ikappa B kinase that leads to the activation of NFkappa-B.
UniGene ID
Hs.644143
UniProt ID (eCommerce)
O43318
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.