human MAP2K7 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human MAP2K7.
shAAV-214922
AAV-h-MAP2K7-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human MAP2K7 (mitogen-activated protein kinase kinase 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
c-Jun N-terminal kinase kinase 2; dual specificity mitogen-activated protein kinase kinase 7; JNK kinase 2; JNK-activating kinase 2; JNKK 2; JNKK2; MAP kinase kinase 7; MAPK/ERK kinase 7; MAPKK 7; MAPKK7; MEK; MEK 7; MKK7; PRKMK7; SAPK kinase 4; SAPKK4; SAPKK-4; stress-activated protein kinase kinase 4
Description (eCommerce)
MAP kinase kinase 7 (MKK7) is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. MKK7 is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stress [taken from NCBI Entrez Gene (Gene ID: 5609)].
Description (Vector)
MAP2K7 is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.
Gene ID
5609
Gene Name (eCommerce)
mitogen-activated protein kinase kinase 7
Gene Name (Vector)
mitogen-activated protein kinase kinase 7
Gene Symbol
MAP2K7
HGNC ID
HGNC:6847
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1281
ORF Size (bp)
1281 bp
Protein Name (eCommerce)
Dual specificity mitogen-activated protein kinase kinase 7
RefSeq ID
NM_145185
RefSeq Synonyms
NM_145185, NM_001297556, NM_001297555, BC038295,
Research Areas
Apoptosis,Cancer,Cardiac Hypertrophy,Cardiology,Cardiovascular,CD95/FAS Signaling,EGFR Signaling,EPO Signaling,Fc Receptor Signaling,Glioma,GnRH Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,JAK-STAT Signaling,Kinase/Phosphatase,MAPK Signaling,Neurobiology,Neurodevelopment,PDGF Signaling,RAC1 Signaling,RANKL-RANK Signaling,Signal Transduction,T-cell Receptor Signaling,TNF Signaling,Toll-like Receptor Signaling,VEGF Signaling
Research Areas (Faceted)
cancer,cardiovascular,cell_biology,developmental_biology,immunology,infectious_disease,neurobiology,signal_transduction
Species
human
Target Sentence
MAP kinase kinase 7 (MKK7) is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. MKK7 is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stress [taken from NCBI Entrez Gene (Gene ID: 5609)].
UniGene ID
Hs.531754
UniProt ID (eCommerce)
O14733
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.