mouse MAP2K7 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Map2k7.
shADV-264176
Ad-m-MAP2K7-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Map2k7 (mitogen-activated protein kinase kinase 7). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
5930412N11Rik; JNKK 2; Jnkk2; MAPKK 7; Mapkk7; MEK 7; Mek7; Mkk7; Prkmk7; sek2
Description (Vector)
Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.
Gene ID
26400
Gene Name (Vector)
mitogen-activated protein kinase kinase 7
Gene Symbol
Map2k7
ORF Size (aa)
1308
ORF Size (bp)
1308 bp
RefSeq ID
NM_011944
RefSeq Synonyms
NM_011944, NM_001291783, NM_001291778, NM_001291777, NM_001164172, NM_001042557, BC070467,
Species
mouse
UniGene ID
Mm.3906
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.