human LZTS2 shRNA silencing AAV

Name 
AAV-h-LZTS2-shRNA
Cat No 
shAAV-214759
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human LZTS2.

shAAV-214759
AAV-h-LZTS2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LZTS2 (leucine zipper tumor suppressor 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
hLZTS2; LAPSER1; leucine zipper putative tumor suppressor 2; leucine zipper, putative tumor suppressor 2; protein LAPSER1
Description (eCommerce)
leucine zipper, putative tumor suppressor 2 (LZTS2) is az negative regulator of katanin-mediated microtubule severing and release from the centrosome. It is required for central spindle formation and the completion of cytokinesis. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. It is a negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BRK4].
Gene ID
84445
Gene Name (eCommerce)
leucine zipper tumor suppressor 2
Gene Name (Vector)
leucine zipper tumor suppressor 2
Gene Symbol
LZTS2
HGNC ID
HGNC:29381
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2010
ORF Size (bp)
2010 bp
Protein Name (eCommerce)
Leucine zipper putative tumor suppressor 2
RefSeq ID
NM_032429
RefSeq Synonyms
NM_032429, NM_001318101, NM_001318100, NM_001318099, BC058938, BC006212,
Research Areas
Apoptosis,Cell Cycle,Cell Division,Cytoskeleton,Signal Transduction,Wnt Signaling
Research Areas (Faceted)
cell_biology,cell_cycle,genetics,signal_transduction
Species
human
Target Sentence
leucine zipper, putative tumor suppressor 2 (LZTS2) is az negative regulator of katanin-mediated microtubule severing and release from the centrosome. It is required for central spindle formation and the completion of cytokinesis. LZTS2 may negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. It is a negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin  [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9BRK4].
UniGene ID
Hs.523221
UniProt ID (eCommerce)
Q9BRK4

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.