human LUM shRNA silencing AAV

Name
AAV-h-LUM-shRNA

Cat No
shAAV-214676

Availability
4-5 weeks

This is an AAV expressing shRNA for silencing of Human LUM.

shAAV-214676

AAV-h-LUM-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human LUM (lumican). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LDC; SLRR2D

Description (Vector)

LUM encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.

Gene ID

4060

Gene Name (Vector)

lumican

Gene Symbol

LUM

HGNC ID

HGNC:6724

ORF Size (aa)

1017

ORF Size (bp)

1017 bp

RefSeq ID

NM_002345

RefSeq Synonyms

NM_002345, BC035997, BC007038,

Species

human

UniGene ID

Hs.406475

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.