human LIG1 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LIG1.
shAAV-213921
AAV-h-LIG1-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LIG1 (DNA ligase 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
DNA ligase 1; DNA ligase I; ligase I, DNA, ATP-dependent; polydeoxyribonucleotide synthase ATP 1
Description (eCommerce)
DNA ligase 1 catalyzes the joining of double-stranded DNA ends during replication, recombination, and repair. Structurally, DNA ligase 1 is toroidal and encircles nicked DNA substrates. The 9-1-1 complex, a DNA damage checkpoint complex, has been reported to associate with DNA ligase 1 and stimulate ligase activity. Mutations in DNA ligase 1 result in immunodeficiency and increased sensitivity to DNA-damaging agents.
Description (Vector)
LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents.
Gene ID
3978
Gene Name (eCommerce)
DNA ligase 1
Gene Name (Vector)
DNA ligase 1
Gene Symbol
LIG1
HGNC ID
HGNC:6598
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2406
ORF Size (bp)
2406 bp
Protein Name (eCommerce)
DNA ligase 1
RefSeq ID
NM_000234
RefSeq Synonyms
NM_001320971, NM_001320970, NM_001289064, NM_001289063, NM_000234, BC110622, BC108318,
Research Areas
Cancer,Cell Cycle,Cell Division,DNA Damage/Repair,DNA Replication,Host-Virus Interactions,Mitochondrion,Telomeric Maintenance
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,genetics,infectious_disease,transcription_translation
Species
human
Target Sentence
DNA ligase 1 catalyzes the joining of double-stranded DNA ends during replication, recombination, and repair. Structurally, DNA ligase 1 is toroidal and encircles nicked DNA substrates. The 9-1-1 complex, a DNA damage checkpoint complex, has been reported to associate with DNA ligase 1 and stimulate ligase activity. Mutations in DNA ligase 1 result in immunodeficiency and increased sensitivity to DNA-damaging agents.
UniGene ID
Hs.1770
UniProt ID (eCommerce)
P18858
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.