human LCK shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human LCK.
shAAV-213750
AAV-h-LCK-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human LCK (LCK proto-oncogene, Src family tyrosine kinase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
IMD22; LSK; p56lck; pp58lck; YT16
Description (Vector)
LCK is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants, encoding the same protein, have been described.
Gene ID
3932
Gene Name (Vector)
LCK proto-oncogene, Src family tyrosine kinase
Gene Symbol
LCK
HGNC ID
HGNC:6524
ORF Size (aa)
1620
ORF Size (bp)
1620 bp
RefSeq ID
NM_005356
RefSeq Synonyms
NM_005356, NM_001330468, NM_001042771, BC013200,
Species
human
UniGene ID
Hs.470627
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.